Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial.
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چکیده
منابع مشابه
Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial.
more potent drugs have become available. Arabinoside adenine and trifluorothymidine (TFT) are both effective and relatively nontoxic alternatives widely used in the management of herpetic disease.' Acyclovir (ACV) (9-(2-hydroxyethoxymethyl) guanine)2 and (E)-5(2-bromovinyl)-2' deoxyuridine),3 recently developed antiviral compounds with potent inhibitory activity against herpes simplex DNA polym...
متن کاملAcyclovir (Zovirax) in herpetic disciform keratitis.
Forty patients with disciform keratitis were randomly assigned to double-blind treatment with 3% acyclovir and 0.01% betamethasone drops or acyclovir and matching placebo. All patients who received the combination healed in a median time of 21 days, while 11 of 19 patients who received acyclovir alone were withdrawn because their condition remained static or worsened (p less than 0.001). The co...
متن کاملAcyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis.
PURPOSE Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant (ACV(R)) HSV-1 and clinical consequences thereof in patients with recurrent HSV-1 keratitis (rHK). METHODS F...
متن کاملA comparison of local and systemic acyclovir in the management of herpetic disciform keratitis.
Forty-three patients with active herpetic disciform keratitis were entered into an open study to compare the efficacy of oral acyclovir (400 mg) with acyclovir ophthalmic ointment (3%) to inhibit viral replication during treatment with 0.05% prednisolone eye drops. All patients, regardless of the mode of therapy, were treated five times a day until they were healed. The mean time to heal in the...
متن کاملA comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis.
Sixty patients were treated with either acyclovir 2% ointment or idoxuridine 1% ointment 5 times a day in a stratified randomised double-blind clinical trial. The 2 antiviral agents were equally effective.
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1982
ISSN: 0007-1161
DOI: 10.1136/bjo.66.8.506